Переводчик Зимарина Лилия

The antitumor effect of ZZZ, XXX, and YYY is primarily realized due to the inhibition of DNA synthesis of a tumor and healthy cells, including the cells of the excretory organs. The toxic effect of cytostatics is described in several scientific publications (1,2,3,4). Renal pathology varies from the mechanical impact of the tumor or metastasis on kidneys or urinary tract to paraneoplastic manifestations, such as nephritis, amyloidosis, and nephropathy induced by pharmaceutical agents. This pathology will be manifested by the increase in the concentration of creatinine, urea, uric acid, and other serum parameters. The enhancement of nephrotoxicity in cancer patients who receive combined chemotherapy with ZZZ is described in the study performed by Gozhenko et al (5). The authors performed a retrospective analysis of the medical histories of 100 patients (70 women and 30 men) aged 32 to 73 years old and revealed the increase in the incidence rate of renal pathologies, such as proteinuria, leukocyturia, erythrocyturia, etc. The successful outcome of chemotherapy was primarily determined by the choice of the drugs that did not exert the nephrotoxic effect. One of the factors that reduce nephrotoxicity can be dose correction in regards to the level of creatinine in the serum (6). At the same time, the effectiveness of the treatment depends on the localization of the tumor, stage of the tumor growth, development of metastasis, associated pathologies, etc. The correct evaluation of these parameters provides satisfactory long-term results of the indicated chemotherapy.

The development of local neuropathy, which is observed in many patients, is based on neural tissue ischemia caused by edema. There are numerous pharmaceutical and physiotherapeutic methods of correction of local edema and neuropathy. Since the etiopathogenesis of this complication after lip contour correction is based on the compression of the surrounding tissues by a conglomerate of the stabilized hyaluronic acid filler and fibrous tissues. The application of hyaluronidase for the acceleration of the biodegradation of the residues of hyaluronic acid and diadynamophoresis with collagenase (collalysin) for the degradation of pathologically produced collagen and anti-edema and the pain-relieving effect is a scientifically grounded combined method of treatment of unfavorable events in cosmetology that significantly improves the esthetic profile and the quality of life of patients.

The efficiency of lithotripsy of different types of stones with minimum damage to the surrounding soft tissues depends on the parameters of laser radiation (wavelength, duration, and pulse power) and the properties of stones (optical, mechanical, and chemical). The prevailing mechanism of stone fragmentation (photothermal or photoacoustic/photomechanical) depends on the intensity, energy, and duration of a pulse. It is believed that laser radiation with pulse duration τ>10 µs causes a significant increase in the temperature in the area of laser exposure in cases with minimal acoustic waves. In such cases, the material of the stone is removed through evaporation, melting, thermomechanical tension, and/or chemical decomposition (a photothermal mechanism). On the contrary, a laser with a short duration of a pulse (

Methods of investigation included general clinical and laboratory tests for the estimation of body mass index (BMI), waist circumference (WC), systolic BP (SBP) and diastolic BP (DBP). Levels of cholesterol (CL), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), plasma glucose, creatinine, uric acid were identified by biochemical assays. All patients had their level of human PlGF (pg/ml) in blood serum estimated by immunological assay XXX (XXX, USA), based on solid-phase enzyme-linked immunosorbent assay (ELISA). At the same time, the authors conducted a morphological study of secundines, which started with a thorough macroscopic examination in the labor ward right after delivery. The material was fixed in a 10% solution of neutral formalin. Paraffin sections were Van Gienson stained with hematoxylin-eosin and picrofuchsin. To keep the groups consistency, the authors examined secundines obtained only after full-term pregnancies.

The great variability of the expression in the epithelium of OE lesions was observed in the proliferative activity of Ki-67. Its level varied from low to relatively high, primarily in the foci with regenerative/dystrophic and true atypia of epithelium, where the expression of other studied antigens was also more significant. The expression of the oncomarker р53 was low but it tended to increase in the foci with regenerative/dystrophic and true atypia of epithelium (statistically insignificant, though). The level of the expression of the inhibitor of apoptosis Bcl-2 was different but it was primarily elevated in the foci with regenerative/dystrophic and true atypia of epithelium.
It should be noted that unlike the foci with atypia, the foci with syncytial papillary regenerative (hyperplastic) alterations with metaplasia with hobnail-like cells and focal hyperplasia (papillary, adenous-solid, with foci of squamous metaplasia) did not differ by the expression of Ki-67, p53, and Bcl-2 from the unaltered epithelium of the endometrioid type.